"Nobel Prize in Medicine" Michael Brown Signed FDC Dated 1974 Todd Mueller COA

Description

Up for auction the  "
Nobel Prize in Medicine" Michael Brown Signed First Day Cover Dated 1965.
This item is certified authentic by Todd Mueller Autographs and comes with their Certificate of Authenticity.
ES-9314
Michael Stuart Brown
ForMemRS
(born April 13, 1941) is an American
geneticist
and
Nobel laureate
. He was awarded the
Nobel Prize in Physiology or Medicine
with
Joseph L. Goldstein
in 1985 for describing the regulation of
cholesterol
metabolism
. Brown was born in
Brooklyn, New York
, the son of Evelyn, a homemaker, and Harvey Brown, a textile salesman.
[4]
[6]
He graduated from
Cheltenham High School
(Wyncote, Pennsylvania). Brown graduated from the
University of Pennsylvania
in 1962 and received his M.D. from the
University of Pennsylvania School of Medicine
in 1966. Moving to the University of Texas Health Science Center in Dallas, now the
UT Southwestern Medical Center
, Brown and colleague
Joseph L. Goldstein
researched cholesterol metabolism and discovered that human cells have
low-density lipoprotein
(LDL) receptors that extract cholesterol from the bloodstream. The lack of sufficient LDL receptors is implicated in
familial hypercholesterolemia
, which predisposes heavily for cholesterol-related diseases. In addition to explaining the underlying pathology of this disease, their work uncovered a fundamental aspect of cell biology -
receptor-mediated endocytosis
. Their findings led to the development of
statin
drugs, the
cholesterol
-lowering compounds that today are used by 16 million Americans and are the most widely prescribed medications in the United States.
[
Their discoveries are improving more lives every year, both in the US and around the world.
[
New federal cholesterol guidelines will triple the number of Americans taking statin drugs to lower their cholesterol, reducing the risk of heart disease and stroke for countless people. Following these important advances, their team of dedicated researchers elucidated the role of lipid modification of proteins (protein
prenylation
) in
cancer
. In 1984 he was awarded the
Louisa Gross Horwitz Prize
from
Columbia University
together with
Joseph L. Goldstein
(co-recipient of 1985 Nobel Prize in Physiology or Medicine). In 1988, Brown received the
National Medal of Science
for his contributions to medicine. In 1993, their trainees
Xiaodong Wang
and Michael Briggs purified the
sterol regulatory element binding proteins
(SREBPs). Since 1993, Drs. Brown, Goldstein, and their colleagues have described the unexpectedly complex machinery by which cells maintain the necessary levels of fats and cholesterol in the face of varying environmental circumstances. Dr. Brown holds the W. A. (Monty) Moncrief Distinguished Chair in Cholesterol and Arteriosclerosis Research; is a Regental Professor of the University of Texas; holds the Paul J. Thomas Chair in Medicine; and is a member of the Board of Scientific Directors at
The Scripps Research Institute
. Frequently mentioned as a candidate for nationally-prominent positions in scientific administration, Dr. Brown, like his colleague
Joseph L. Goldstein
, elects to continue hands-on involvement with research, leading a research team that typically includes a dozen doctoral and postdoctoral trainees. He and his colleague are among the most highly cited scientists in the world.